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Whole Genome Sequencing for Fetuses

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Genome Sequencing for Fetuses

In June, researchers at the University of Washington in Seattle announced the successful sequencing of a complete fetal genome using nothing more than snippets of DNA floating in its mother's blood. Unlike earlier techniques, it was completely noninvasive and posed no risks to the baby-to-be. They said the test might be clinically available in just five years -- an optimistic outlook, perhaps, but even if it takes a decade, the consequences could be profound.

After all, genetic tests for newborn babies are already routine. Millions of parents would almost undoubtedly want to scan their fetuses, too. The scans might pick up potentially fatal conditions early, saving lives and easing pain. The scans would also, however, detect more ambiguous medical signals, such as predispositions to disease, or information about traits like personality or physique. What would parents do with that information? What should they do? Is there a limit to how much genetic information parents want about their babies? And how much of that information should be shared with a child? None of these questions have clear answers, and they'll be debated in years to come.

Images: A 3-D ultrasound of a fetus in its first trimester. (Biagio Azzarelli/Flickr)


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